This article is part of the Special Issue entitled “Novel Treatments for Traumatic Brain Injury”. Edem cerebral difuz Seciunea: Forum medical.dus pe cineva la urgente cu dureri de cap acute, varsaturi, etc. neoplasm pulmonar) -instalare acuta->edem cerebral cu simptome de hipertensiune. Diagnosticul de urticarie si angioedem este unul clinic si se face pe baza observarii directe a leziunilor tipice: papule eritematoase, pruriginoase care palesc la apasare si au caracter fugace (in general nu persista mai mult de 24 ore), respectiv edem asimetric, alb, la nivelul extremitatilor insotit de usor prurit/senzatie de arsura/durere, ce se poate remite spontan sau cu tratament. We thus aim to provide a translational synopsis of present and future strategies targeting CE after TBI in the context of a paradigm shift towards precision medicine. Potential future molecular targets for treating CE are presented based on pathophysiologic mechanisms. Edem cerebral - n cretere rapid acumulare de lichid n esuturi cerebrale, fr furnizarea de ngrijiri medicale adecvate care duce la moarte.Baza tabloului clinic este n cretere treptat sau rapid deteriorare a pacientului i aprofundarea tulburrilor de contiin, nsoite de semne meningeale i atonie muscular. While an exhaustive discussion of all pathways with putative contributions to CE is beyond the scope of this review, the roles of some key contributors are highlighted, and references are provided for further details. There is a discussion of identified cellular/cytotoxic contributors to CE, as well as mechanisms that influence blood-brain-barrier (BBB) disruption/vasogenic edema, with the caveat that this distinction may be somewhat artificial since molecular processes contributing to these pathways are interrelated. This review focuses on a contemporary understanding of various pathophysiologic pathways contributing to CE, with a subsequent description of potential targeted therapies. Se traduce uneori printr-o hipertensiune intracraniana cu urmatoarele semne: paralizii, voma, cefalee si uneori coma.
After treatment of mass lesions in severe TBI, an important focus of acute neurocritical care is evaluating and managing the secondary injury process of CE and resultant intracranial hypertension. Edem cerebral reprezinta cresterea in volum a creierului, consecutiva unei cresteri a continutului de apa al tesuturilor sale. Edemul cerebral reprezint creterea presiunii intracraniene i poate fi o consecin a unui traumatism, accident vascular cerebral sau a unei infecii provocate de virusuri, bacterii sau parazii. CE is a leading cause of in-hospital mortality, occurring in >60% of patients with mass lesions, and ∼15% of those with normal initial computed tomography scans. Edemul cerebral din ce cauze apare, cum se manifest, care e tratamentul. Cerebral edema (CE) and resultant intracranial hypertension are associated with unfavorable prognosis in traumatic brain injury (TBI).
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